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Naina Mohamed Pakkir Maideen

(Dubai Health Authority)

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Drug interactions; pharmacokinetic interactions; verapamil; diltiazem; cyp3a enzymes; p-gp transporter.

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Drug interactions of non-dihydropyridine calcium channel blockers involving cyp3a enzymes and p-gp transporter protein

Author : Naina mohamed pakkir maideen

Keyword : Drug interactions; pharmacokinetic interactions; verapamil; diltiazem; cyp3a enzymes; p-gp transporter.

Subject : Pharmacology

Article Type : Review article

DOI : 10.33263/briac104.026032

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Drug interactions of non-dihydropyridine calcium channel blockers involving cyp3a enzymes and p-gp transporter protein QR Code

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Abstract : Non-dihydropyridine CCBs such as verapamil and diltiazem are useful in the management of angina, certain arrhythmias and hypertension and they are known inhibitors of CYP3A enzymes and P-gp transporter. Hence, they can potentiate the adverse effects of substrates of CYP3A enzymes and P-gp transporter. This article focuses on the drug interactions of non-dihydropyridine CCBs involving CYP3A enzymes and P-gp transporter protein. To predict and prevent adverse outcomes, the prescribers and the pharmacists are required to be aware of the possible drug interactions of non-dihydropyridine CCBs.

Article by : Naina Mohamed Pakkir Maideen

Article add date : 2021-12-21


How to cite : Naina mohamed pakkir maideen. (2021-December-21). Drug interactions of non-dihydropyridine calcium channel blockers involving cyp3a enzymes and p-gp transporter protein. retrieved from https://www.openacessjournal.com/abstract/947

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