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Naina Mohamed Pakkir Maideen

(Dubai Health Authority)

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Drug interactions
acetaminophen
paracetamol
cyp2e1
cyp1a2
ugt enzymes

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Drug interactions of acetaminophen (paracetamol) involving cyp and ugt enzymes

Author : Naina mohamed pakkir maideen

Keyword : Drug interactions, acetaminophen, paracetamol, cyp2e1, cyp1a2, ugt enzymes

Subject : Pharmacology

Article Type : Review article

DOI : 10.13187/ejm.2019.1.30

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Abstract : Acetaminophen (Paracetamol) is the most frequently used Over-The-Counter (OTC) antipyretic and analgesic drug, worldwide. The metabolism of Acetaminophen is mediated by phase II reactions (UDP-glucuronosyl transferases (UGT)-mediated glucuronidation and sulfation) and phase I oxidative reactions mediated by Cytochrome P450 (CYP) enzymes including CYP2E1 and CYP1A2. The drugs inducing CYP2E1 and CYP1A2 enzymes and the drugs inhibiting UDP-glucuronosyl transferases (UGTs) may increase the exposure of NAPQI resulting in elevated risk of hepatotoxicity. The risk of acetaminophen-associated hepatotoxicity might be elevated due to concomitant use of certain medications including Isoniazid, Antiepileptic drugs, Tyrosine kinase inhibitors and Alcohol. Acetaminophen may increase the international normalized ratio (INR) by potentiating the anticoagulant effect of warfarin. To prevent possible adverse drug interactions, the prescribers and pharmacists must discuss with their patients about the use of OTC Acetaminophen.

Article by : Naina Mohamed Pakkir Maideen

Article add date : 2021-12-21


How to cite : Naina mohamed pakkir maideen. (2021-December-21). Drug interactions of acetaminophen (paracetamol) involving cyp and ugt enzymes. retrieved from https://www.openacessjournal.com/abstract/937

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