Author : Utsang kumar; rekha khandia; shailja singhal; nidhi puranik; meghna tripathi; atul kumar pateriya; raju khan; talha bin emran; kuldeep dhama; ashok munjal; taha alqahtani; ali m. alqahtani
Keyword : Epb41l3; codon usage bias; rscu; gc contents; translational efficiency; mutational pressure; natural selection
Subject : Oncology
Article Type : Original article (research)
DOI : 10.3390/cancers13112739
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Abstract : The present study envisaged the codon usage pattern analysis of tumor suppressor gene EPB41L3 for the human, brown rat, domesticated cattle, and Sumatran orangutan. Most amino acids are coded by more than one synonymous codon, but they are used in a biased manner. The codon usage bias results from multiple factors like compositional properties, dinucleotide abundance, neutrality, parity, tRNA pool, etc. Understanding codon bias is central to fields as diverse as molecular evolution, gene expressivity, protein translation, and protein folding. This kind of studies is important to see the effects of various evolutionary forces on codon usage. The present study indicated that the selection force is dominant over other forces shaping codon usage in the envisaged organisms.
Article by : Utsang Kumar
Article add date : 2021-06-05
How to cite : Utsang kumar, rekha khandia, shailja singhal, nidhi puranik, meghna tripathi, atul kumar pateriya, raju khan, talha bin emran, kuldeep dhama, ashok munjal, taha alqahtani, ali m. alqahtani. (2021-June-05). Insight into codon utilization pattern of tumor suppressor gene epb41l3 from different mammalian species indicates dominant role of selection force. retrieved from https://www.openacessjournal.com/abstract/751