Author : S. azhagu madhavan
Keyword : Keywords: hepatoprotective, insulin, diabetes mellitus, pancreatic hormone, stz
Subject : Pharmacy
Article Type : Original article (research)
Article QR Code
Article File : Full Text PDF
Abstract : Diabetes mellitus is an endocrine, metabolic disorder in which the homeo- stasis of carbohydrate and lipid metabolism is improperly regulated by the pancreatic hormone, insulin, ultimately resulting in increased blood glucose. In our study, diabetes was induced in rats by single intraperito- neal injection of Streptozotocin (STZ) at a dose of 45mg/kgb.w. and the hepatoprotective efficacy of aqueous extract of Costus spicatus (ACS) at a dose of 500 mg/kg b.w. was studied. Diabetes mellitus is associated with progressive metabolic derangement, worsening glycemic control, and morphological changes in the liver, pancreas and other organs. Diabetes is characterized by high blood plasma glucose levels and high concentration of liver enzymes like SGOT, SGPT and ALP in hepatocytes of the liver leaks into the circulation as a result of damage to cell membrane of hepatocytes. In the present study, administration of ACS to STZ induced diabetic animals restored the blood plasma glucose and liver enzymes to normal level which is comparable to the anti-diabetic efficacy of Glibenclamide a synthetic drug. Though both showed its anti-diabetic efficacy, ACS exerted its anti-diabetic activity without damaging the liver in comparison with Glibenclamide which damaged the liver. .
Article by : Dr S AZHAGU MADHAVAN
Article add date : 2021-01-07
How to cite : S. azhagu madhavan. (2021-January-07). Hepatoprotective and antidiabetic effect of aqueous extract of costus spicatus jacq. rhizome extract in streptozotocin induced diabetic rats –histological study. retrieved from https://www.openacessjournal.com/abstract/535