Author : Seharish saleem1, madiha kanwal1*, ghulam abbas miana1, rashida nafees2, nafees3, saima maqsood1, komal naeem1 and haroon iqbal2
Keyword : Erythrina suberosa, bark extract, phytochemicals, ht-144 cell line, anticancer, anti-inflammatory
Subject : Pharmacognosy
Article Type : Original article (research)
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Abstract : Plants are considered great and indispensable source of food, energy, cosmetics and even medicines. Since prehistoric culture, humans rely on plants for their growth, survival and still cultivated vegetables and plants as a source of novel chemical compounds with pharmacological properties. Current study was designed to separate active constituents of Erythrina suberosa bark extract through phytochemical screening and evaluated their biological activities such as anticancer, anti-inflammatory and antioxidant activities. The bark extract of E. suberosa contained saponins, glycosides, alkaloids, tannins, terpenoids and phenols, identified by phytochemical analysis. Furthermore, the bark extract shows the concentration dependent cytotoxicity against HT-144 cell lines evaluated through MTT assay. In addition, the E. suberosa bark extract also exhibited anti-inflammatory effect at higher doses (400 mg/kg) and moderate antioxidant activity is noticed through DPPH free radical assay. These findings indicate that E. suberosa bark extract exhibited prominent anticancer and anti-inflammatory activity and might be serve as a potent therapeutic agent in future studies.
Article by : madiha kanwal
Article add date : 2020-11-18
How to cite : Seharish saleem1, madiha kanwal1*, ghulam abbas miana1, rashida nafees2, nafees3, saima maqsood1, komal naeem1 and haroon iqbal2. (2020-November-18). Phytochemical investigation and biological evaluation of erythrina suberosa bark extract. retrieved from https://www.openacessjournal.com/abstract/366