Author : Jadhav ankush p.*, datar p. a., kedar t. r., kore k. j., shete r. v.
Keyword : Simultaneous equation method; validation; perindopril; amlodipine; indapamide; ich.
Subject : Pharmacy
Article Type : Original article (research)
Article QR Code
Article File : Full Text PDF
Abstract : A new, simple, accurate, precise and reproducible UV-Spectrophotometry method is being developed for the simultaneous estimation of Perindopril, Amlodipine and Indapamidein tablet dosage form. It is smart, more time & money saving novel method because this method does not require any derivatization step or complex algorithms. The stock solutions were prepared in methanol. The λmax for Perindopril, Amlodipine and Indapamide were 232 nm, 244 nm and 258 nm resp. The Perindopril, Amlodipine and Indapamide obeyed Beer’s law in concentration range of 0.4-1.2 µg/ml, 1-3 µg/ml and 0.5-2.5 µg/ml respectively. Results of analysis of simultaneous equation method were analyzed and validated for various parameters according to ICH guidelines for Accuracy, Precision, Linearity, Robustness, LOD and LOQ. The proposed method is highly sensitive, precise and accurate, therefore can be used for intended purpose.
Article by : Ankush P. Jadhav
Article add date : 2020-10-09
How to cite : Jadhav ankush p.*, datar p. a., kedar t. r., kore k. j., shete r. v.. (2020-October-09). Novel spectrophotometric multicomponent analysis of a ternary mixture of perindopril, amlodipine and indapamide by simultaneous equation method. retrieved from https://www.openacessjournal.com/abstract/281