Author : Rukshi naaz, seema sinha, surender singh, gaurav gupta
Keyword : Malaria; plasmodium falciparum; drug resistance; artemisinin; k13
Subject : Biological
Article Type : Review article
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Abstract : The blood stage of malaria parasites is responsible for all the morbidity and mortality associated with malaria. During the blood stage, malaria parasites invade and multiply within host erythrocytes. The process of erythrocyte invasion requires specific interactions between host receptors and parasite ligands. Many of the key parasite proteins that bind host receptors are localized in apical organelles called micronemes but blood-stage malaria vaccines that target single antigens involved in erythrocyte invasion have not induced optimal protection in field trials due to antigenic polymorphisms and molecular redundancy. Vaccines that target multiple invasion-related parasite proteins may inhibit erythrocyte invasion more efficiently. Therefore the importance of developing a receptor-blocking blood-stage vaccine approach against P. falciparum that targets the erythrocyte binding domains of multiple parasite proteins, blocking their interaction with their receptors and thus inhibiting erythrocyte invasion.
Article by : Rukshi Naaz
Article add date : 2020-09-02
How to cite : Rukshi naaz, seema sinha, surender singh, gaurav gupta. (2020-September-02). The hunt for an effective malaria vaccine. retrieved from https://www.openacessjournal.com/abstract/107