Author : Snehal kothawale1 *, deepti mhaske2 , atish velhal3 , prakash jadhav4 , vivekumar redasani5
Keyword : Topical drug delivery; emulgel; aceclofenac; carbopol 934; factorial design; in vitro diffusion studies
Subject : Pharmacy
Article Type : Original article (research)
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Abstract : The formulated and evaluated aceclofenac emulgels as a potential alternative topical treatment on rheumatism. Methods: Nine preliminary aceclofenac emulgels (Formulations F1-F9) were developed using a 3 2 factorial design. The effects of carbopol-934 and Locust bean gum as gelling agents and wintergreen oil drug release enhancers, respectively, were connected with four medicinal parameters of the created emulgels at one hour and eight hours, namely viscosity, spreadability, and cumulative drug release. To optimised aceclofenac emulgels (Formulations F1 to F9) were created, formulated, and assessed using the obtained data and the Design Expert modelling programme. DDSolver dissolution software was used to model drug release kinetics1 . This study aimed to develop and test alternative formulations of a topical emulgel containing aceclofenac employing polymers with varying concentrations such as Carbopol 934 and modified locust bean gum and wintergreen oil was utilised to improve penetration2 .
Article by : snehal kothawale
Article add date : 2023-09-09
How to cite : Snehal kothawale1 *, deepti mhaske2 , atish velhal3 , prakash jadhav4 , vivekumar redasani5. (2023-September-09). Aceclofenac emulgel for topical management of rheumatism: design, development & in vitro characterization. retrieved from https://www.openacessjournal.com/abstract/1338